In a video posted to her Twitter account, she called serving as the first lady the “greatest honour of my life.”
“I have been inspired by incredible Americans across our country who lift up our communities through their kindness and courage, goodness and grace,” Ms Trump said.
“As Donald and I conclude our time in the White House, I think of all of the people I have taken home in my heart, and their incredible stories of love, patriotism and determination.”
Without specifically mentioning the Capitol Hill riots, Ms Trump called for peace in the final days of the White House transition.
“Be passionate in everything you do,” she said. “But always remember that violence is never the answer and will never be justified.”
The inauguration on January 20 (local time) is being prepared under intense security.
More than 20,000 National Guard troops were being dispatched across the city to bolster security.
She also said she and Mr Trump “grieve for the families who have lost a loved one due to the pandemic.”
“As the world continues to confront the COVID-19 pandemic, I thank all of the nurses, doctors, healthcare professionals, manufacturing workers, truck drivers, and so many others who are working to save lives,” she said.
It has been confirmed Mrs Trump will not be giving incoming First Lady Jill Biden a tour of the White House.